30 tablets
 
Exemestane, known under the brand name Symex, is a steroidal, irreversible aromatase inhibitor. It is a drug used primarily by people who need a permanent reduction in estrogen levels without the risk of relapse after discontinuation. Exemestane works at the cellular level, deactivating aromatase, which prevents estrogen from returning to baseline levels even after discontinuing the drug.
 
Exemestane Mechanism of Action

Exemestane works by permanently binding to the aromatase enzyme, which leads to its deactivation. The enzyme becomes inactive, which permanently lowers estrogen levels in the body. This makes Exemestane particularly useful for athletes who want to achieve consistent estrogen control without the rebound effect typical of non-steroidal inhibitors.

Pharmacokinetics of Exemestane

Half-life: Exemestane has a shorter half-life of about 9 hours, but its effects last a long time.
Efficiency: At a dose of 25 mg, Exemestane blocks 80-90% of aromatase activity within 24 hours. This effect lasts 40% for the next 72-120 hours, making it effective even with less frequent use.
Recovery time: Full recovery of estrogen levels occurs after about 120 hours, but the effect is so durable that the relapse effect is minimal.

Advantages and disadvantages of using Exemestane

Advantages:

Long-lasting effect - elimination of the estrogen relapse effect after discontinuation of use.
Support for IGF-1 metabolism - unlike non-steroidal inhibitors, Exemestane supports the hepatic metabolism of IGF-1, which may be beneficial for athletes striving to improve muscle mass.
Long-lasting effect at a relatively low dose - due to its high effectiveness, Exemestane can be used less frequently.
 
Exemestane Dosage

Exemestane is most commonly used at a dose of 25 mg per day. The effect begins relatively quickly and is effective for 3-5 days. As with other aromatase inhibitors, the dose should be adjusted to individual needs and based on the results of hormonal tests.